Sensoring
Microsensoring has a higher spatial (10-25 μm diameter) and temporal resolution (second-scale recording of neurotransmitters) than microdialysis. Therefore, it can provide more spatial-temporal resolution measurements and capture the fast change neurotransmitter levels, glucose or other physiological compounds.
In our lab we routinely monitor brain glutamate and periphery glucose levels in both anesthetized and freely moving animals.
Analyte + Enzyme - FAD > Enzyme - FADH2 + X
Enzyme - FADH2 + O2 > Enzyme - FAD + H2O2
Reaction of an oxidase enzyme
Currently we have sensors available for the monitoring of
- Lactic acid
- Glutamate
- Glucose
- NO
- H2O2
- Acetylcholine
- Choline
Sensors can be applied in
- Brain
- Spinal cord
- Subcutanous
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