Microdialysis

Local release of the following neurotransmitters can be monitored:

• Acetylcholine
• Dopamine
• Gamma-amino butyric acid (GABA)
• Histamine / tele-Methyl-Histamine
• Norepinephrine
• Serotonin
• Glutamate
• Glycine
• D- and L- serine
• DOPAC, 5-HIAA, HVA and MHPG

But also these other factors that influence neuronal activity can be monitored:

• Choline
• Adenosine, cAMP and cGMP
• Glucose / lactate / pyruvate
• Glycine
• Taurine
• Kynurenine pathway metabolites
• Ethanol-amides

The following administration routes are available:

• Locally (i.e. via the microdialysis probe, sometimes referred to as 'reverse or retro dialysis'; or iontophoretically)
• Systemically (i.p., s.c. or i.v. through a pemanent catheter)
• Both routes combined

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SymDAQ(TM)

Neurotransmitters are derivatized using SymDAQ for increased sensitivity in LC-MS/MS detection. The SymDAQ label contains an intrinsic charge and reduces the ion suppression effects. Importantly, this method allows accurate analysis at low concentrations.

• Norepinephrine 50 pM - 8 nM
• Dopamine 50 pM - 8 nM
• Serotonin 50 pM - 8 nM
• Histamine 250pM - 40 nM
• GABA 800 pM - 320 nM
• Glutamate 20 nM - 8 μM
• Glycine 20 nM - 8 μM

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